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Title:
Matrix-insensitive protein assays push the limits of biosensors in medicine
Authors:
Gaster, RS; Hall, DA; Nielsen, CH; Osterfeld, SJ; Yu, H; Mach, KE; Wilson, RJ; Murmann, B; Liao, JC; Gambhir, SS; Wang, SX
Author Full Names:
Gaster, Richard S.; Hall, Drew A.; Nielsen, Carsten H.; Osterfeld, Sebastian J.; Yu, Heng; Mach, Kathleen E.; Wilson, Robert J.; Murmann, Boris; Liao, Joseph C.; Gambhir, Sanjiv S.; Wang, Shan X.
Source:
NATURE MEDICINE 15 (11): 1327-U130 NOV 2009
Language:
English
Document Type:
Article
KeyWords Plus:
SPIN-VALVE SENSORS; OVARIAN-CANCER; SUPERPARAMAGNETIC NANOPARTICLES; BIOLOGICAL APPLICATIONS; DNA DETECTION; MICROARRAYS; LACTOFERRIN; BIOMARKER
Abstract:
Advances in biosensor technologies for in vitro diagnostics have the potential to transform the practice of medicine. Despite considerable work in the biosensor field, there is still no general sensing platform that can be ubiquitously applied to detect the constellation of biomolecules in diverse clinical samples (for example, serum, urine, cell lysates or saliva) with high sensitivity and large linear dynamic range. A major limitation confounding other technologies is signal distortion that occurs in various matrices due to heterogeneity in ionic strength, pH, temperature and autofluorescence. Here we present a magnetic nanosensor technology that is matrix insensitive yet still capable of rapid, multiplex protein detection with resolution down to attomolar concentrations and extensive linear dynamic range. The matrix insensitivity of our platform to various media demonstrates that our magnetic nanosensor technology can be directly applied to a variety of settings such as m!
olecular biology, clinical diagnostics and biodefense.
Reprint Address:
Wang, SX, Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA.
Research Institution addresses:
[Hall, Drew A.; Murmann, Boris; Wang, Shan X.] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA; [Gaster, Richard S.; Gambhir, Sanjiv S.] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; [Gaster, Richard S.] Stanford Univ, Med Scientist Training Program, Stanford, CA 94305 USA; [Nielsen, Carsten H.; Gambhir, Sanjiv S.] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA; [Nielsen, Carsten H.] Rigshosp, Dept Clin Physiol Nucl Med & Positron Emiss Tomog, Copenhagen, Denmark; [Nielsen, Carsten H.] Univ Copenhagen, DK-1168 Copenhagen, Denmark; [Nielsen, Carsten H.] Tech Univ Denmark, Dept Elect Engn, Sect Biomed Engn, Lyngby, Denmark; [Osterfeld, Sebastian J.; Wilson, Robert J.; Wang, Shan X.] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA; [Osterfeld, Sebastian J.; Yu, Heng] MagArray Inc, Sunnyvale, CA USA; [Mach, Kathleen E.; Liao, Joseph C.] Stanford Univ, Dept Urol, Stanford, CA 94305 USA; [Liao, Joseph C.; Gambhir, Sanjiv S!
.; Wang, Shan X.] Stanford Univ, Biox Program, Stanford, CA 94305 USA
E-mail Address:
sgambhir@stanford.edu; sxwang@stanford.edu
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Cited Reference Count:
33
Times Cited:
0
Publisher:
NATURE PUBLISHING GROUP; 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
Subject Category:
Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental
ISSN:
1078-8956
DOI:
10.1038/nm.2032
IDS Number:
516LM
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