Cited Article: Ghosh, S. Carbon nanotube flow sensors
Alert Expires: 22 OCT 2009
Number of Citing Articles: 2 new records this week (2 in this e-mail)
Organization ID: 3b97d1bbc1878baed0ab183d8b03130b
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Title:
A mechanical model of the gating spring mechanism of stereocilia
Authors:
Lim, K; Park, S
Author Full Names:
Lim, Koeun; Park, Sukyung
Source:
JOURNAL OF BIOMECHANICS 42 (13): 2158-2164 SEP 18 2009
Language:
English
Document Type:
Article
Author Keywords:
Hair cell; Biomimetics; Gating spring; Nonlinear amplification
KeyWords Plus:
SENSORY HAIR BUNDLES; EARS WORKS WORK; TIP LINKS; MECHANOELECTRICAL TRANSDUCTION; SPONTANEOUS OSCILLATION; CELL STEREOCILIA; ADAPTATION; STIFFNESS; AMPLIFICATION; COCHLEA
Abstract:
The stereocilium is the basic sensory unit of nature's mechanotransducers, which include the cochlear and vestibular organs. In noisy environments. stereocilia display high sensitivity to miniscule stimuli, effectively dealing with a situation that is a design challenge in micro systems. The gating spring hypothesis suggests that the mechanical stiffness of stereocilia bundle is softened by tip-link gating in combination with active bundle movement, contributing to the nonlinear amplification of miniscule stimuli. To demonstrate that the amplification is induced mechanically by the gating as hypothesized, we developed a biomimetic model of stereocilia and fabricated the model at the macro scale. The model consists of an inverted pendulum array with bistable buckled springs at its tips, which represent the mechanically gated ion channel. Model simulations showed that at the moment of gating, instantaneous stiffness softening generates an increase in response magnitude, which !
then sequentially occurs as the number of gating increases. This amplification mechanism appeared to be robust to the change of model parameters. Experimental data from the fabricated macro model also showed a significant increase in the open probability and pendulum deflection at the region having a smaller input magnitude. The results demonstrate that the nonlinear amplification of miniscule stimuli is mechanically produced by stiffness softening from channel gating. (C) 2009 Elsevier Ltd. All rights reserved.
Reprint Address:
Park, S, Korea Adv Inst Sci & Technol, Dept Mech Engn, 335 Gwahangno, Taejon 305701, South Korea.
Research Institution addresses:
[Lim, Koeun; Park, Sukyung] Korea Adv Inst Sci & Technol, Dept Mech Engn, Taejon 305701, South Korea
E-mail Address:
sukyungp@kaist.ac.kr
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Cited Reference Count:
45
Times Cited:
0
Publisher:
ELSEVIER SCI LTD; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Subject Category:
Biophysics; Engineering, Biomedical
ISSN:
0021-9290
DOI:
10.1016/j.jbiomech.2009.05.040
IDS Number:
502RO
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Title:
Carbon nanotube volatile organic liquid sensor
Authors:
Song, Y; Choi, J
Author Full Names:
Song, Youngsik; Choi, Jaewu
Source:
APPLIED PHYSICS LETTERS 95 (12): Art. No. 123122 SEP 21 2009
Language:
English
Document Type:
Article
KeyWords Plus:
WATER; GAS
Abstract:
Volatile organic liquid sensors with two distinct configurations are developed for a future biosensor using laterally grown carbon nanotubes (CNTs) from two isolated metal electrodes. In the first configuration, the CNTs grown from each electrode weakly contact each other, and the charge transport between them is based on tunneling. In the second configuration, the CNTs in the array are covered with a silicone composite paste and strongly contact each other; Ohmic transport behavior is observed. The signal modulation amplitude with exposure to the volatile organic liquid is higher than two orders in magnitude. The sensing mechanism is based on the capillary force between CNTs and the swelling property of the silicone paste induced by the organic liquids. (C) 2009 American Institute of Physics. [doi:10.1063/1.3238325]
Reprint Address:
Choi, J, Kyung Hee Univ, Dept Informat Display, 1 Hoeki Dong Dondaemoon Ku, Seoul 130701, South Korea.
Research Institution addresses:
[Choi, Jaewu] Kyung Hee Univ, Dept Informat Display, Seoul 130701, South Korea; [Song, Youngsik] Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA
E-mail Address:
jaewuchoi@khu.ac.kr
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Cited Reference Count:
16
Times Cited:
0
Publisher:
AMER INST PHYSICS; CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA
Subject Category:
Physics, Applied
ISSN:
0003-6951
DOI:
10.1063/1.3238325
IDS Number:
499RX
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